Vitamins and Supplements You Should NEVER Combine

When it comes to our health, vitamins and supplements play an important role in filling nutritional gaps in our diet. However, not all combinations are beneficial. In fact, some combinations can interfere with absorption or have negative effects. Understanding which vitamins and supplements you should never combine can help you optimize their effectiveness and prevent potential health risks. Here are the do’s and don’ts when combining these essential nutrients.

fat-soluble and water-soluble vitamins
Understanding the difference between fat-soluble and water-soluble vitamins is the key to knowing how to properly combine them. Fat-soluble vitamins like vitamin D are best absorbed when taken with a meal because they dissolve easily in fat. On the other hand, water-soluble vitamins, such as vitamin C and B12, dissolve in water and are usually absorbed better on an empty stomach. Therefore, mixing fat-soluble and water-soluble vitamins can interfere with the vitamin absorption process and reduce the vitamin’s effectiveness.
calcium and iron
Calcium and iron are two essential minerals that should ideally be taken separately. Taking calcium together may interfere with iron absorption and reduce its effectiveness. To maximize the benefits of both supplements, we recommend taking them at least 2 hours apart. An easy way to remember is to take one in the morning and one in the evening to ensure optimal absorption and utilization by your body.
zinc and copper
Zinc and copper are micronutrients that compete for absorption in the body. Both supplements may be less effective when taken together. To avoid this, purchase a supplement that provides a balanced ratio of zinc and copper, or stagger your intake throughout the day by at least two hours apart. This allows each nutrient to be absorbed and utilized more efficiently by the body.

magnesium and calcium
Magnesium and calcium are both essential for bone health and muscle function, but they can interfere with each other’s absorption when taken at the same time. To avoid this interference, it is recommended to take magnesium and calcium supplements at different times of the day. Spaced doses optimize absorption and prevent interactions that can impair effectiveness.
Vitamin C and Vitamin B12

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Both vitamin C and vitamin B12 are essential for a variety of bodily functions, but high doses of vitamin C can interfere with the absorption and metabolism of vitamin B12. To get the most out of these nutrients, it’s best to take them separately or at least two hours apart. This prevents potential interference and allows each vitamin to effectively perform its role in supporting overall health.