summary: Researchers say that late-night exercise may be more effective at boosting metabolism and burning fat than late-night exercise. It may prove valuable for those trying to lose fat.
sauce: Karolinska Institute
Physical activity at appropriate times of the day appears to increase fat metabolism, at least in mice.
A new study from the Karolinska Institutet in Sweden and the University of Copenhagen in Denmark found that mice that exercised during the early active phase (corresponding to morning exercise in humans) had a higher metabolism than those that exercised during normal hours. shown. holiday.
The results were published in a journal PNAS.
Because biological processes depend on cellular circadian rhythms, physical activity at different times of the day can affect the body in different ways.
To see how the time of day exercise affects fat burning, researchers at the Karolinska Institutet and the University of Copenhagen found that after high-intensity exercise at two points in the daily cycle: , studied mouse adipose tissue. Early active and early resting phases (corresponding to human late-night and late-night sessions, respectively).
The researchers studied different markers of fat metabolism and analyzed which genes were activated in adipose tissue after exercise.
Independent of food intake
Researchers have shown that physical activity during the early stages of activity increases the expression of genes involved in adipose tissue breakdown, thermogenesis (thermogenesis), and adipose tissue mitochondria, leading to a higher metabolic rate. I discovered that These effects were observed only in mice that exercised during the early active phase and were independent of food intake.
“Our results suggest that late-night exercise may be more effective than late-night exercise in terms of boosting metabolism and burning fat. It may prove to be of value to too many people,” says Professor Julien.
Improve the health benefits of exercise
Mice and humans share many basic physiological functions, and mice are well-established models of human physiology and metabolism. However, there are also important differences, such as mice being nocturnal.
“Appropriate timing appears to be important for improving the body’s energy balance and the health benefits of exercise, but it is difficult to draw reliable conclusions about our findings and their relevance to humans.” , more research is needed.
About this Exercise and Metabolism Research News
author: press office
sauce: Karolinska Institute
contact: Press Office – Karolinska Institutet
image: image is public domain
Original research: open access.
“Post-exercise metabolism in mouse adipose tissue is time-dependent” Pendergrast, Logan A. et al. PNAS
overview
Post-exercise metabolism in mouse adipose tissue is time-dependent
See also
The circadian clock is a cell-autonomous transcriptional-translational feedback mechanism that predicts and adapts physiology and behavior to different phases of the day. A variety of factors, including hormones, temperature, food intake, and exercise, can act on tissue-specific peripheral clocks to alter the expression of genes that affect metabolism over time.
The purpose of this study was to elucidate the effects of exercise timing on adipose tissue metabolism. RNA-sequencing was performed on the inguinal adipose tissue of mice immediately after maximal exercise or sham treatment in the early resting or early active phases.
Only during the early active period did exercise cause an immediate increase in serum non-esterified fatty acids. Furthermore, early active phase exercise increased the expression of markers of thermogenesis and mitochondrial proliferation in inguinal adipose tissue.
In vitro, synchronized 3T3-L1 adipocytes exhibited timing-dependent differences Adrb2 Formula as well as greater lipolytic activity. Therefore, adipose tissue responses to exercise are time-of-day sensitive and may be driven in part by the circadian clock.
To determine the effect of feeding state on temporal responses to exercise, experiments were replicated in early resting mice fasted for 10 h to mimic early active metabolic states.
Fasting for 10 h produced a lipolytic response similar to that observed after active-phase exercise, but did not replicate the transcriptomic response. This suggests that the observed gene expression changes are not caused by the feeding state.
In conclusion, acute exercise elicits timing-specific effects on adipose tissue to maintain metabolic homeostasis.
