Hypertensive medication Lilmenidine It has been shown to slow the aging of worms. This is the effect that in humans it can help us live for many years and stay healthy in the years that follow.
Previous studies have shown that lylmenidine mimics the effect of calorie restriction on cellular levels. Reducing the available energy while maintaining nutrients in the body has been shown to extend lifespan In some animal models.
Whether this is translated into human biology or a potential risk to our health? Ongoing discussion. Finding ways to achieve the same benefits without the cost of extreme calorie cutting can lead to new ways to improve health in geriatric age.
A study published in 2023 revealed that both old and young caenorhabditis elegans As scientists had hoped, worms treated with this drug (usually used to treat hypertension) lived longer and presented higher measurements with a variety of health markers, just as they restrict calories.
“For the first time, we were able to demonstrate that lylmenidine can extend lifespan in animals.” Molecular biologist Joan Pedro Magalges saidfrom the University of Birmingham, UK.
“I am keen to explore whether lylmenidine may have other clinical applications.”
C. Elegance Worms are my favorite research. Because many of those genes are similar to our genome counterparts. But despite these similarities, it is still a rather distant relationship with humans.
Further testing showed that calorie restriction-related gene activity is found in kidney and liver tissues of mice treated with lylmenidine.
In other words, we believe that some of the changes that calorie restriction gives to animals confer certain health benefits.
Another finding was that a biological signaling receptor called Nish-1 is important in the efficacy of lylmenidine. This particular chemical structure could be targeted in future attempts to improve lifespan and slow aging.
“When Nish-1 was removed, we found that the life-extensive effect of lylmenidine was abolished,” the researchers explained in them. paper.
“Critical, rescue of the Nish-1 receptor has restored an increase in lifespan during treatment with lylmenidine.”
A low-calorie diet is difficult and difficult to have a variety of side effects, including thin hair, dizziness, and brittle bones.
It’s still early on, but the idea is that this hypertensive medication can provide the same benefits as a low-calorie diet while being easy on the body.
What makes lylmenidine a promising anti-aging drug is that it is taken verbally, already widely prescribed, and its side effects are rare and relatively mild (in some cases, including kinetic pit, insomnia, and drowsiness).
While there is still a long way to go to understand whether lylmenidine serves as an actual human anti-aging drug, early signs of these worms and mouse testing are promising. We know more now about what lylmenidine can do and how it works.
“In a global aging population, the benefits of slowing aging are even slightly enormous.” Magalhas said.
This study was published in Senescent cells.
An earlier version of this article was published in January 2023.
