Pediatric patients with cystic fibrosis may be colonized with commonly asymptomatic bacteria Clostridioides difficile However, the incidence of C difficile infection (CDI) was not increased.
A team led by Seth A. Reasoner of the Division of Pathology, Microbiology and Immunology, Division of Molecular Etiology, Vanderbilt University Medical Center, determined the rate of asymptomatic C. difficile colonization, risk, and risk in pediatric patients with cystic fibrosis. identified factors, and sequelae.
People with cystic fibrosis are usually treated with antibiotics for the rest of their lives. These patients also have altered gut microbiome, a known risk factor for CDI.
Nonetheless, adults with cystic fibrosis are rarely diagnosed with CDI, and asymptomatic C. difficile colonization frequently occurs. Clostridium difficile colonization has been reported in 22-50% of adult patients with cystic fibrosis, which is higher than the 5-10% rate in the general population.
There are many reasons why clinicians are concerned about colonization in patients with cystic fibrosis.
“First, it poses a diagnostic challenge for patients presenting with signs and symptoms of CDI,” the authors wrote. “Constipation is the main symptom of CF dysmotility, but loose stools and diarrhea also occur in association with pancreatic insufficiency and overflow diarrhea.”
In this study, investigators collected 108 unique stool samples from pediatric patients with cystic fibrosis without acute gastrointestinal symptoms and performed NAAT C difficile testing at prospective follow-up. sample, C. difficile Toxin B gene.
The patient population was 18 years old or younger and diagnosed with cystic fibrosis at Monroe Carell Jr. Children’s Hospital in Vanderbilt.Cystic fibrosis was confirmed by medical record verification of 2 pathogenic CFTR variants with 2 sweat chloride tests ≥60 mmol/L or genetic testing
In this study, researchers found that 32% (n = 35) of pediatric patients with cystic fibrosis were colonized with C. difficile without acute gastrointestinal symptoms. Results were similar to those seen in adults with cystic fibrosis, although these studies differed in his C. difficile test approach.
Furthermore, no patient with colonized C. difficile developed CDI during the 90-day follow-up period.
“taller than [body mass index] BMI and exposure to certain antibiotic classes (cephalosporins, fluoroquinolones, and vancomycin) were significantly associated with patients. C. difficile colonization,” the author writes. “No child developed symptomatic CDI within 90 days of enrollment.”
A study earlier this year found that a patient’s target body mass index (BMI) is cystic fibrosis You should reconsider. Although the prevalence of overweight and obesity in patients with cystic fibrosis is rising, it is unclear whether there are benefits associated with gaining weight compared to normal reference ranges.
Compared to overweight or obese patients, normal-weight cystic fibrosis patients were associated with a higher forced expiratory volume in the first second of exhalation, according to the results of a new study. People of normal weight also had higher rates of cystic fibrosis-related diabetes (CFRD) and pancreatic insufficiency (PI).
Overweight or obese individuals were associated with a higher forced expiratory volume in the first second of exhalation compared with normal weight individuals. Analysis of lung function showed high heterogeneity.
This result indicates that nutritional status influences maintenance of organ function in cystic fibrosis patients. According to the researchers, a daily protocol should include nutritional strategies that bring BMI closer to the upper limit of his normal BMI.
the study, “Prevalence, risk factors, and sequelae of asymptomatic Clostridioides difficile colonization in children with cystic fibrosis.‘ was published online. Journal of Cystic Fibrosis.
