Approximately 65% of US adults consume sugar-sweetened beverages daily. Chronic liver disease is a leading cause of morbidity and mortality worldwide and can lead to liver cancer and liver disease-related deaths. Researchers at Brigham and Women’s Hospital, a founding member of the Massachusetts General Brigham Health Care System, have linked consumption of sugary and artificially sweetened beverages with the incidence of liver cancer and chronic liver disease. led one of the first studies to examine. death.The results are posted below jam.
To our knowledge, this is the first study to report an association between consumption of sugary drinks and chronic liver disease mortality. ”
Dr. Longgang Zhao, First Author, Brighams Channing Network Medical Division
Zhao is a Postdoctoral Fellow working with Xuehong Zhang, Senior Author, MBBS, ScD, Channing Division. “If our findings are confirmed, they may pave the way for public health strategies to reduce the risk of liver disease based on data from large, geographically diverse cohorts.”
This observational study included nearly 100,000 postmenopausal women from a large prospective study by the Women’s Health Initiative. Participants reported consumption of regular soft drinks, fruit drinks (excluding fruit juices), and then artificially sweetened beverages three years later. Participants were followed for a median of over 20 years. The researchers examined self-reported incidence of liver cancer and deaths from chronic liver disease, including fibrosis, cirrhosis, and chronic hepatitis, and further validated against medical records and the National Death Index.
A total of 98,786 postmenopausal women were included in the final analysis. 6.8% of women who drank one or more sugary drinks daily had an 85% higher risk of liver cancer and death from chronic liver disease compared to women who drank less than three sugary drinks a month. 68% higher risk.
The authors point out that the study is observational, cannot infer causality, and relies on self-reported responses regarding intake, sugar content, and outcomes. More research is needed to test this risk association and to understand why sugary drinks increase the risk of liver cancer and liver disease. Moreover, further studies are needed to integrate genetics, preclinical and experimental studies, and omics data to elucidate potential mechanisms.
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Reference magazines:
Zhao, L., other. (2023). Sugary and artificially sweetened beverages and risk of death from liver cancer and chronic liver disease. JAMA. doi.org/10.1001/jama.2023.12618
