severe frostbite Occur When the skin and underlying tissues are exposed to subzero temperatures, blood vessels narrow, restricting blood flow. Eventually, as circulation slows and heat decreases, ice crystals grow within the tissues.
Frostbite usually occurs on the extremities, such as fingers and toes, but can also occur on the nose, ears, and other parts of the body. People with health problems such as vascular disease or diabetes, people without shelter or proper clothing, and people who work long hours outdoors during the winter are especially at risk.
The most severe cases of frostbite require amputation of the affected limb or finger. 2021 Survey found At least 20 percent of patients injured by frostbite are disabled by amputation, and such injuries disproportionately impact the homeless population.
In a randomized clinical setting trial Of the 47 patients with severe frostbite, none of the 16 patients who received the new drug alone required amputation, but three patients who received iloprost and other drugs required amputation. There were 9 patients. Do not administer iloprost.
“This new option gives physicians a tool to prevent life-changing amputations of frostbitten fingers and feet,” said Norman Stockbridge, director of the division of cardiology and nephrology in the FDA’s Center for Drug Evaluation and Research. ” said in the news. release.
An Eikos spokesperson said Aurumin will be available this spring, but the drug’s price has not yet been determined.
