unusual condition Posterior cortical atrophy (PCA) involves strange and troubling problems with visual and spatial cognition, such as difficulty judging distance, perceiving motion, and recognizing objects, and new research has previously linked it to Alzheimer's disease. This has been highlighted in detail above.
PCA and Alzheimer's disease have long been linked to each other because they share many of the same pathological changes in the brain. However, the rarity of PCA has made it difficult for researchers to fully evaluate his PCA in relation to Alzheimer's disease.
To address this, an international research team analyzed data from 1,092 patients with PCA and found that PCA was a very strong predictor of Alzheimer's disease. Obvious Alzheimer's brain changes are observed in 94 percent of cases and most likely contribute to PCA. .
“We need more awareness of PCA so that clinicians can alert them.” To tell Marianne Chapleux, a neuropsychologist at the University of California, San Francisco (UCSF), says:
“Most patients see an optometrist when visual symptoms begin, but ophthalmologists may not be able to recognize PCA. We need better tools in the field.”
One of the possible positive effects of this research is that it may cause people to experience symptoms such as: Symptoms of PCA We checked out as soon as possible. The average age of onset of this disease is 59 years, which is several years younger than the average age of onset of Alzheimer's disease, and the average time from onset of symptoms to first diagnosis is 3.8 years.
The study pointed out that there are many similarities between PCA and Alzheimer's disease in terms of amyloid and tau levels in the brain, and the accumulation of these proteins has long been associated with the development of dementia. Ta.
However, there are also some differences that may give researchers clues about the best course of treatment.
“PCA patients have more tau lesions in the back of the brain, which is involved in processing visuospatial information, compared to other Alzheimer's disease patients.” To tell says Renaud La Joie, a neuropsychologist at UCSF. “This may make it more suitable for anti-tau therapy.”
The researchers involved in this new study say their work provides more information about how Alzheimer's disease develops and how both Alzheimer's disease and PCA begin to affect the brain. I hope that this will lead to deeper understanding.
This study included people from 16 countries and is the most comprehensive review of PCA to date, offering a different perspective on dementia due to its close connection to Alzheimer's disease. I'll give it to you.
“From a scientific perspective, we need to really understand why Alzheimer's disease specifically targets visual areas of the brain rather than memory areas.” To tell said Gil Rabinovich, a neurologist at UCSF.
“Our study found that 60 per cent of patients with PCA were women. A deeper understanding of why women appear to be more susceptible is one important area for future research. There is one.”
This research lancet neurology.
