New research has identified proteins that appear to be essential for hair growth and hair follicle protection. When called MCL-1, it can be targeted by the treatment of certain types of alopecia, such as alopecia.
Researchers, led by a team from the Dukenus School of Medicine in Singapore and the Walter and Elizahall Institute of Medicine in Australia, found that the animals lost their hair late when MCL-1 production was blocked in mice.
Hair follicles go through a cycle of rest and growth, and MCL-1 plays an important role in the latter phase. Proteins do not appear to affect quiescent stages or early development Hair liningbut.
“Acute MCL‑1 deletion rapidly depletes activated hair follicle stem cells and completely blocks hair loss-induced fur regeneration in adult mice, but does not affect resting hair follicle stem cells.” write Researcher of published papers.
it was Already known MCL-1 played an important role in protecting different types of tissues from apoptosis. Programmed death of redundant or damaged cells to maintain body function.
Regarding hair, MCL-1 prevents follicular stem cells from being stressed or damaged as their follicle stem cells “wake up” from rest. Without MCL-1 to protect them, these cells will cease to function.
The team was also able to uncover new details about the function of MCL-1, identifying ways to suppress another protein called BAK and how MCL-1 is regulated by a signaling pathway called ERBB. These details will help you develop new ways of hair removal treatment.
“These findings suggest that ERBB signaling regulates MCL-1 expression through translational regulatory mechanisms. write.
Because this study is based solely on mice, there is good reason to believe that the same process is happening above our own heads, but the findings need to be replicated in human clinical studies.
It is also worth keeping in mind that there are many different types of alopecia and there are various causes of contributions. If treatments focused on increasing MCL-1 are developed for a day, they will not work for any type of hair removal.
Aside from these limitations, this one protein handiwork is an important revelation regarding the hair follicle’s ability to grow hair. Findings can also inform future research on other processes affected by MCL-1. Cancer cell death.
“This study advances understanding of the molecular mechanisms underlying hair follicle regeneration and provides new insights into how stem cell survival and tissue regeneration are tuned.” write Researcher.
“These findings could have broader implications for controlling STEM and progenitor cell survival in tissue regeneration and cancer spread.”
This study is published in Natural Communication.
