This photo taken in Paris on February 23, 2023 shows the diabetes drug Ozempic (semaglutide) manufactured by Danish pharmaceutical company Novo Nordisk.
Joel Saget | AFP | Getty Images
Patients taking Ozempic or Wegovy, blockbuster obesity drugs, lose weight when they stop taking the drugs.
Karin Kondeknape, senior vice president of global drug discovery at Novo Nordisk, said in an interview with CNBC. Healthy Returns his summit on Wednesday. “As long as you keep your intake and output the same, you can control your weight.
Conde-Knape added that the rate of weight gain after stopping Wegovy varies from person to person, “some people come back sooner, others slower.”
Available data suggest that most people regain most of their weight within 5 years of stopping Wegovy, with approximately 50% of their weight regained after 2-3 years. Some individuals may actually gain more weight after stopping the drug than they initially lost. Studies have shown that people who stop taking Ozempic regain weight as well. It has been. Novo Nordisk manufactures both prescription drugs.
She said it has to do with how the drugs work. They mimic a hormone produced in the gut called GLP-1 that sends signals to the brain when a person is full. Calling it a “direct effect on satiety,” he noted that the drug can also control the types of food people crave.
But she said GLP-1 doesn’t “rewire a neural network to actually define new weight setpoints.” So, according to Conde-Knape, weight loss may not be permanent.
The Danish pharmaceutical company needs to conduct more research and clinical trials to understand the drivers of these weight gain rates, but “very importantly, it definitely needs to stay”. Kondeknape said.
Her statement comes after Ozempic and Wegovy have been thrust into the US national spotlight in recent years for being a “weight loss miracle” in a country obsessed with body image. It showed that: Descent About 15% less body weight.
Hollywood celebrities, social media influencers and even billionaire tech moguls Elon Musk He reportedly used popular pen-shaped injections to shed unwanted weight.
Wegovy has been flying off the shelves since winning the FDA approval In June 2021, I started “chronic weight management”. So is Ozempic. Ozempic was first approved for the treatment of diabetes and is now used off-label for weight loss.Its popularity caused widespread shortages last year, with Novo Nordisk increased production of Wegoby.
Shortages and other factors, such as uninsured out-of-pocket costs and unpleasant side effects, have forced some people to stop taking Ozempic or Wegovy.there’s a lot of it left I complain Weight rebound that is difficult to control.
According to Conde-Knape, the data so far show weight loss is maintained even with long-term use of the drug. Is not …
“The longer the treatment period, the more we need to see how much more the patient can achieve,” she said.
