TLigonelline found in coffee Although it decreases during sarcopenia, increasing its level can improve physical performance.
Sarcopenia is a condition characterized by the progressive loss of skeletal muscle mass and function and poses a significant global health challenge, especially among the growing elderly population.
A recent study by Switzerland’s Nestlé Research and the National University of Singapore Yong Lu Lin School of Medicine (NUS Medicine), in collaboration with other academic institutions, sheds light on a potential therapeutic avenue involving the natural molecule trigonelline. Masu. [1]. Trigonella is present in the body and is also readily available from dietary sources such as coffee and fenugreek seeds.
Longevity Technology: At the core of the pathophysiology of sarcopenia are age-related cellular changes, including decreased mitochondrial function and decreased nicotinamide adenine dinucleotide (NAD+) levels. These changes contribute to muscle tissue deterioration and functional decline, and in particular, a research consortium identified a correlation between decreased trigonelline levels and sarcopenia in older adults.
In preclinical models, administration of trigonelline demonstrated efficacy in alleviating symptoms of sarcopenia. Specifically, trigonelline supplementation led to increased NAD+ levels, enhanced mitochondrial activity, and preserved muscle function. According to the authors, these findings suggest that trigonelline supplementation may serve as an NAD+-boosting strategy to reduce age-related muscle loss. [1].
This study also showed that trigonelline supplements can: Nematode In animal models, it was associated with improved mitochondrial respiration and biogenesis, reduced muscle wasting, and increased longevity and mobility through an NAD+-dependent mechanism involving the sirtuin pathway. Supplementing the diet of male mice with trigonelline increased muscle strength and prevented age-related fatigue. [1].
Study results highlight the therapeutic potential of trigonelline supplementation in addressing sarcopenia. Although a stop at Starbucks has no short-term effect, trigonelline is a promising intervention against age-related muscle decline. Furthermore, the identification of trigonelline as a regulator of NAD+ levels highlights the importance of trigonelline in cellular metabolism and aging processes.
Associate Professor Vincenzo Sorrentino of NUS Medicine’s Healthy Longevity Translational Research Program and corresponding author of the paper said: “Our findings extend the current understanding of NAD+ metabolism with the discovery of trigonelline as a novel NAD+ precursor and raise the possibility of establishing interventions for NAD+ metabolism.” Healthy Longevity and Age-Related Diseases NAD+ producing vitamins that can be applied to both [2]”
Nutrition and physical activity are important lifestyle recommendations for maintaining healthy muscles as you age. “Through our collaborative research, we were excited to discover that natural molecules derived from food crosstalk with the hallmarks of cellular aging. The benefits of trigonelline on cellular metabolism and muscle health during aging are promising. This opens up new possibilities for translational applications,” said Jerome Feige, Head of Physical Health, Nestlé Research. [2].
Sarcopenia is a significant global health burden, with significant implications for both individual well-being and health systems worldwide. The discovery of the role of trigonelline in regulating cellular pathways associated with sarcopenia opens the door to potential interventional avenues, and further research is warranted to elucidate the precise mechanism of trigonelline’s action and its clinical utility. Coffee flavored fenugreek seeds, anyone?
Image courtesy of NUS Yong Lu Lin School of Medicine
[1] https://www.nature.com/articles/s42255-024-00997-x
[2] https://medicine.nus.edu.sg/news/natural-molecule-found-in-coffee-and-human-body-increases-nad-levels-improves-muscle-function-during-aging/
