Newswise — INDIANAPOLIS – Researchers and clinicians at the Regenstrief Institute, the Indiana University School of Medicine, and the Mayo Clinic found that music interventions could help critically ill elderly on ventilators in hospital intensive care units (ICUs). We are conducting studies at multiple facilities to establish that we can reduce the chances. ) can also develop delirium and improve brain health after ICU. This study is her one of the first to measure exposure to music, as the researchers continue their pioneering investigation into the potential of music to reduce or prevent delirium.
One million adults in the United States receive mechanical ventilation in hospital ICUs each year. As many as 80% of these individuals experience delirium, a syndrome of acute brain dysfunction, while in the ICU. Delirium puts the patient in her ICU, lengthens her hospital stay, and increases her risk of death. Delirium is also associated with long-term complications such as cognitive impairment and dementia.
People with delirium experience sudden changes in mental status, often feeling confused, disoriented, or distracted. People experiencing delirium can become hyperactive, agitated, and restless. Rapid mood swings, difficulty concentrating, and hallucinations and anxiety are common.
“Because there are no effective drugs for delirium, there is a great need for nonpharmacologic therapies to prevent or manage delirium,” said co-principal investigator of the study, of the Regenstrief Institute and IU School of Medicine. Babar Khan, MD, MS said. “This study is done to establish that music reduces delirium in her ICU patient on a ventilator. Our goal is to become the standard of care for ICU patients.”
Dr. Khan, former president of the American Delirium Society, is the developer of CAM-ICU-7, an easy-to-use delirium severity assessment tool. The CAM-ICU-7 was used in studies to score delirium on a scale of 0 (no delirium) to he 7 (severe), providing objectivity in brain injury assessment. This information is essential not only for current and future brain health management by clinicians, but also for future use in clinical research by researchers. He also developed a post-critical care model for ICU survivors.
In a current study to reduce delirium, 160 ventilated adults over the age of 50 were randomly assigned to one of two groups within 72 hours of ICU admission. A participant in the music arm of this study received her 1 hour of slow tempo (60–80 beats per minute) instrumental music twice a day for 7 days via noise-cancelling headphones. The other arm receives a placebo consisting of a silent audio track administered in the same manner and duration. In addition to twice-daily delirium assessments, pain and anxiety will be assessed daily.
The primary outcome of improvement in delirium is measured by the number of days the patient survives and is delirium-free, not comatose, during 7 days of exposure to music or silence.
For both groups, a specially designed computer application (app), piloted by researchers at Regenstrief, IU, and Mayo, tracks the length and frequency of listening sessions. For those in the music sector of research, the app also collects data on music selection from extensive playlists.
Three months after hospital discharge, the effects of music exposure on cognition, as measured by memory, attention, information processing, speed, and executive cognitive function of music recipients to silent tracks, and study participants’ mood and Anxiety is assessed.
“As a side effect of this study, we are investigating the downstream effects of relaxing, slow-paced music on brain health conditions important to ICU survivors,” said study co-investigator Sikandar Khan. Director of the COVID-19 Recovery Program for the Elderly at the Regenstrief Institute and Indiana University Health Intensive Care Unit (ICU) Survivor Center.
The clinical trial “Music-induced delirium reduction in critically ill and ventilated older adults” is supported by the National Institutes of Health’s National Institute on Aging. A paper describing the study protocol, “Music-listening (DDM)-induced delirium reduction in critically ill ventilated older adults in the intensive care unit: a two-arm parallel-group randomized clinical trial.,” was published in a peer-reviewed open access journal trialIn addition to co-lead author Dr. Babar Khan and co-lead author Linda Chlan, PhD, RN, Mayo Clinic. Regenstrief Investigator Dr. Sikandar Khan, author of the Trials paper is Salwa Moiz, MBBS, Kiran Naqvi, MBBS, and Lori Rawlings, BSN, RN, all of whom he is a member of the Regenstrief Institute. Associate authors Sarah Seyffert, MD, Matthew Coghlan, MD, Anthony J. Perkins, MS, Sujuan Gao, PhD, and all of the IU School of Medicine. Patil Balozian, M.D., Jason Nasser, M.D., Emilio Abi Rached, M.D., Yasser Jamil, M.D., all from the American University of Lebanon. J. Downs Hunter, Area 10 Labs and Annie Heiderscheit, PhD, University of Augsburg.
Baber Khan, MD, MS
In addition to his appointment as a research scientist at the Regenstrief Institute and associate director of the Regenstrief Institute’s Center for Aging at Indiana University, Babar Khan, MD, MS is Professor of Medicine and Floyd and Reba Smith Professor at the IU School of Medicine. respiratory disease.
Sikandar Khan, DO, MS
Sikandar Khan is a research scientist at the Regenstrief Institute and an assistant professor at the Indiana University School of Medicine, focusing on delirium in intensive care units and non-pharmacological approaches to the prevention and treatment of this devastating brain disorder.
About Regenstrief Institute
Founded in Indianapolis in 1969, Regenstrief Institute is a regional, national and global leader dedicated to a world where better information empowers people to end disease and achieve true health. A key research partner at Indiana University, her Regenstrief and his research scientists are responsible for a growing number of major healthcare innovations and research. Examples range from developing global health information technology standards that enable the use and interoperability of electronic medical records, to improving patient-physician communication, to informing practice and improving the lives of patients around the world. It extends to creating models of care that improve.
Sam Regenstriefis a nationally successful entrepreneur from Connorsville, Indiana who founded a research institute with the goal of making healthcare more efficient and accessible to all. His vision continues to guide the Institute’s research mission.
About IU School of Medicine
IU School of Medicine It is the largest medical school in the United States and is annually ranked among the nation’s top medical schools by US News & World Report. The school offers a rich campus life in nine Indiana cities, including rural and urban Indiana cities consistently recognized for quality medical education, access to cutting-edge medical research, and livability. It offers.
