1. Anemia during pregnancy is associated with changes in the child’s brain structure, including decreased volume of the bilateral caudate, putamen, and corpus callosum
Evidence Rating Level: 2 (good)
It is estimated that 38% of pregnant women worldwide are anemic. Although anemia is a known risk factor for poor maternal and infant health, limited research has been conducted to determine the association between maternal anemia and brain structure in children. This cohort study sought to further explore this association by examining subsequent brain structural changes in 147 mother-infant pairs. adjusted for the trimester of the The child underwent magnetoencephalography at her 2–3 years of age, and hemoglobin was measured only if she visited the hospital between birth and her MRI. Of 147 mothers, 31% were found to be anemic during pregnancy. After adjusting for covariates, maternal anemia was not found to be associated with overall brain volume in children, but significant associations between individual structures were identified, including: bilateral tails; Smaller volume of nucleus nucleus, putamen and corpus callosum (-5.30%) [95% CI, −7.01 to −3.59, −4.33% [95% CI, −5.74 to −2.92]−7.75% [95% CI, −11.24 to −4.26] Respectively). Not all children in the study had hemoglobin measurements, and we did not find that anemia in children was associated with changes in brain volume. of HIV and alcohol use, and of anemia in children due to the small sample size, which includes high-risk groups. In addition, this study did not include longitudinal findings, which limited the study’s ability to further extrapolate subsequent neurodevelopmental outcomes. Overall, this study shows that maternal anemia is associated with brain development in children, and that optimizing interventions to manage maternal anemia positively impacts brain development. There is a possibility.
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