Lipid profiles are reproducibly altered in patients with severe psychiatric disorders, according to a study published online Jan. 25. JAMA Psychiatry.
Dr. Anna Tkachev and colleagues at the Skolkovo Institute of Science and Technology in Moscow examined the blood lipidomic profiles of people with severe psychiatric disorders (schizophrenia, major depressive disorder, etc.). [MDD]bipolar disorder [BPD]). The analysis included 980 of his inpatients and outpatients in mental health hospitals in Western Europe, China, and Russia, and 572 of his controls.
The researchers found that 77 lipids were significantly altered in schizophrenia patients and controls across participants in all three countries. Lipid-based predictive models are able to distinguish between schizophrenic patients and diagnostic controls (area under the receiver operating characteristic curve, 0.86–0.95). Similar lipidomic changes were seen in patients with BPD and MDD (BPD, r = 0.89; MDD, r = 0.92). These changes were not associated with symptom severity, medication, demographic or environmental variables.
“This lipid alteration signature may represent a characteristic marker of severe psychiatric disorders, demonstrating the potential for translation into clinically applicable testing procedures,” the authors wrote.
One of the authors disclosed patents related to the subject of his research and financial ties to the pharmaceutical industry.
For more information:
Anna Tkachev et al. Characterization of plasma lipid changes in individuals with schizophrenia, depression and bipolar disorder. JAMA Psychiatry (2023). DOI: 10.1001/jamapsychiatry.2022.4350
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