1. People with higher BMI had lower baseline vitamin D serum metabolite levels than those with lower BMI.
2. Decreased effectiveness of vitamin D supplementation was observed in individuals with high BMI. This may be due to slowed metabolism.
Evidence Rating Level: 2 (good)
Vitamin D is an essential micronutrient with well-established links to various diseases such as rickets and osteomalacia. New research suggests that vitamin D deficiency may be linked to obesity and excess weight. -OHD) and obesity in a fully randomized controlled trial. A total of 16,515 adult participants free of cancer and cardiovascular disease at baseline were enrolled. These participants provided a baseline blood sample and reported their height and weight on questionnaires. The participant was then followed up 2 years after him. In his first VITAL study, participants were randomly assigned to his two groups, a vitamin D supplementation group and a placebo group. The results of this cohort analysis showed that, before randomization, serum total 25-OHD values were lower in his BMI category with higher. However, after randomization, the intervention group receiving vitamin D supplementation showed increases in total 25-OHD levels, although these increases were significantly lower in those with higher BMI. This suggests that while D supplementation may increase vitamin D-related serum biomarkers, responses were decreased among individuals who were overweight at baseline. proposed altered responses to vitamin D supplementation and subsequent effects on health outcomes in individuals with high BMI. There are some limitations to be aware of. For example, although the randomized nature of the study reinforced the validity of these results, certain factors such as study drug adherence and loss of follow-up were not considered in the methodology. All participants, regardless of baseline BMI, were provided with the same amount of vitamin D supplements, although individuals of different body weights may have different vitamin requirements. This post hoc study of a randomized clinical trial suggests that overweight individuals may be less responsive to vitamin D supplementation. Further research into the mechanisms behind this phenomenon is needed.
Click to read the survey on JAMA Network Open
Image: PD
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