Researchers are literally welcomed as a revolutionary development of highly heart failure, saying that the damaged heart can be patched to help them work.
According to a recent surveyHeart failure affects more than 64 million people around the world, as causes such as heart attack, hypertension, and coronary artery disease.
In the case of heart transplantation, there is a shortage of available organs, but the artificial heart pump is expensive and the speed of complications increases.
Scientists believe that they created a breakthrough by creating a embedded patch composed of the heart muscles that can help the organs contraction.
Professor INGO Kutschka, a co -author of German University Medical Center Gettingen, said: “
Patches are created from cells collected from blood, are “re -programs” to act as stem cells, and may develop into any cell type in the body.
In the case of patches, these cells turn into myocardial and connective tissue cells. They are embedded in collagen gel and grow with custom -made molds before the hexagonal patches obtained as a result are attached to the membrane in the array. In the case of humans, the size of this membrane is about 5cm x 10cm.
Professor Wolfram-Hubertus Zimmermann, another author of Gettingen’s work at the University Medical Center, said that patch muscles are only 4-8 years old.
“We are embedding young muscles in patients with heart failure,” he said.
The team says that patches are important, as injecting muscle cells in the heart directly into the heart can lead to tumor growth or irregular heartbeat development.
However, the patch can administer more myocardial cells at higher preservation, and there seems to be no risk of such an incredible effect.
Write in Nature magazineZimmermann and colleagues report on how they have tested a healthy akage monkey patch, and do not find any evidence of death or illness related to patches, irregular heartbeats, tumor formation, patches.
When the team studied animal hearts up to six months after the patch was embedded, they found a heart wall thickening within the number of patches used.
The team also tested monkey patches for a disease similar to chronic heart failure. In this case, the team found signs of improving heart function, such as improving the ability to contract the heart wall.
Later, the researcher applied an approach to a 46 -year -old woman with advanced heart failure. In this case, the patch was made from human cells collected from the donor and sutured to the patient’s heartbeat in a minimal invasive surgery.
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Three months later, the stable patient was able to analyze the removed heart after the heart transplant. Researchers have found that patches have survived and blood supply has developed.
The use of cells from donors means that immunosuppressing is required, but researchers say that it is too expensive, and it takes too long to create patches from patient cells with urgent needs. Masu. Patch and better safety test.
The team says that it takes 3-6 months to see the patch treatment effect. In other words, it is not suitable for all patients. However, 15 patients are already patching.
“We hope that our progressive clinical trials will show whether this operated cardiomyophagia will improve the patient’s heart function,” Kutschka said.
Zimmermann said that his goal was not necessarily to replace heart transplantation.
“We are currently providing new treatments to patients who have received palliative care and have 50 % mortality within 12 months,” he said.
Professor Cyan Harding of Imperial College London explained this research as a groundbreaking study, but it is necessary to work further because the patch heart cells are not completely mature and the blood flow is slow. I mentioned.
Professor Ipsita Roy, Professor Ipsita Roy, also welcomed the job, pointed out that the involvement was invasive than heart transplant.
“It’s a great work. I was really impressed,” she said. “The concept is very clear. You can patch your heart anywhere where your heart is damaged.”