overview: Studies have found associations between dehydration in adults and an increased risk of chronic health conditions and advanced biological aging.
sauce: NIH (National Institutes of Health)
Adults who drink enough water appear to be healthier, develop fewer chronic diseases such as heart and lung disease, and live longer than those who don’t. eBio Medicine.
Using health data collected from 11,255 adults over 30 years, researchers analyzed the association between serum sodium levels (which rise as water intake decreases) and various indicators of health.
They found that adults with serum sodium levels in the high end of the normal range were more likely to develop chronic disease and show signs of advanced biological aging than those with serum sodium levels in the moderate range. Adults with higher levels were also more likely to die at a younger age.
“Results suggest that adequate hydration may slow aging and prolong disease-free life.” National Institute of Health (NHLBI), part of the NIH.
The study expands on research published in March 2022 by the scientists, who found a link between a high range of normal serum sodium levels and an increased risk of heart failure. Both findings are derived from atherosclerosis risk in the community. (ARIC) study, which includes substudies of thousands of black and white adults across the United States. His first ARIC substudy began in 1987 and helped researchers better understand risk factors for heart disease and formed clinical guidelines for its treatment and prevention.
In this latest analysis, researchers assessed information shared with study participants during five medical visits, the first two in their 50s and the last two in those aged 70-90. To allow a fair comparison of how hydration correlates with health outcomes, the researchers investigated whether adults who had high levels of serum sodium at baseline check-in, or who had no effect on serum sodium levels. We excluded adults with underlying medical conditions, such as obesity, that could lead to
Next, we evaluated how serum sodium concentrations correlated with biological aging, assessed by 15 health markers. This includes factors such as systolic blood pressure, cholesterol and blood sugar, providing insight into how well each person’s cardiovascular, respiratory, metabolic, renal and immune systems are functioning. We also adjusted for factors such as age, race, biological sex, smoking status, and hypertension.
They found that adults with high normal serum sodium levels, with a normal range of 135 to 146 milliequivalents per liter (mEq/L), were more likely to show signs of biological aging. This was based on indicators such as metabolic and cardiovascular health, lung function, and inflammation.
For example, adults with serum sodium concentrations above 142 mEq/L have a 10–15% increased chance of being biologically older than chronological age compared to those in the range of 137–142 mEq/L,144 50% increase for levels above mEq/L. Similarly, levels of 144.5 to 146 mEq/L were associated with a 21% increased risk of premature death compared to the range of 137 to 142 mEq/L.
Similarly, adults with serum sodium concentrations greater than 142 mEq/L have an associated risk of up to 64% for developing chronic diseases such as heart failure, stroke, atrial fibrillation, and peripheral arterial disease, as well as chronic lung disease, diabetes, and dementia. Increased. Conversely, adults with serum sodium concentrations between 138 and 140 mEq/L had the lowest risk of developing chronic disease.
The findings do not prove causality, the researchers noted. Randomized controlled trials are needed to determine whether optimal hydration can promote healthy aging, prevent disease, and extend lifespan. can provide and guide individual health behaviors.
“People with serum sodium above 142 mEq/L would benefit from assessing fluid intake,” said Dmitrieva. She said most people can safely increase their fluid intake to meet recommended levels.
For example, the National Academy of Medicine suggests that most women consume about 6 to 9 cups (1.5 to 2.2 liters) of fluid each day, and men consume 8 to 12 cups (2 to 3 liters) of fluid. I’m here.
Others may require medical guidance for underlying health conditions. It’s about making sure we’re doing it,” said Manfred Boehm, M.D., study author and director of the Institute for Cardiovascular Regenerative Medicine.
“Physicians may also need to follow the patient’s current treatment regimen, including limiting fluid intake for heart failure.”
The authors also cited a study that found that about half of people worldwide do not meet their total daily fluid intake recommendations, which often start at 6 cups (1.5 liters).
“At the global level, this could have a huge impact,” Dmitrieva said. “Dehydration is the most common factor in increasing serum sodium. Therefore, our results suggest that maintaining adequate hydration may slow the aging process and prevent or delay chronic disease.” It is suggested from
Funding: This research was supported by the NHLBI’s Intramural Research Department. ARIC research is supported by research contracts from the NHLBI, NIH, and the Department of Health and Human Services.
About this Aging and Neuroscience Research News
author: press office
sauce: NIH (National Institutes of Health)
contact: Press Office – NIH
image: image is public domain
Original research: open access.
“High normal serum sodium in middle age as a risk factor for accelerated biological aging, chronic disease, and premature death” Dmitrieva NI, Gagarin A, Liu D and others eBio Medicine
See also
overview
High normal serum sodium in middle age as a risk factor for accelerated biological aging, chronic disease, and premature death
Background
It is known that some people age faster than others, some enter old age disease-free, and some develop age-related chronic diseases. With rapidly aging populations and new epidemics of chronic diseases, discovering mechanisms that slow the aging process and implementing preventive measures poses new challenges for biomedical research and public health. In mice, lifelong water restriction shortens lifespan and promotes degenerative changes. Here we test the hypothesis that optimal hydration may slow the aging process in humans.
method
A cohort analysis of data from the atherosclerosis risk in community study was performed on middle-aged enrollees (45-66 years, n = 15,752) and 25 years of follow-up. Serum sodium was used as a surrogate for hydration habits. To estimate the relative rate of aging, we calculated biological age (BA) from age-dependent biomarkers to assess the risk of chronic disease and early death.
findings
The analysis showed a 39% increased risk of developing chronic disease with serum sodium above 142 mmol/l in middle age (hazard ratio (hazard ratio) [HR] = 1.39, 95% confidence interval [CI]:1.18–1.63) and >144 mmol/l, with a 21% higher risk of early death (HR = 1.21, 95% CI: 1.02–1.45). People with serum sodium >142 mmol/l were up to 50% more likely to be older than their chronological age (OR = 1.50, 95% CI: 1.14–1.96). Higher BA was associated with higher risk of chronic disease (HR = 1.70, 95% CI: 1.50–1.93) and higher early mortality (HR = 1.59, 95% CI 1.39–1.83).
interpretation
People with serum sodium >142 mmol/l in middle age are at increased risk of becoming biologically older, developing chronic diseases, and dying prematurely. Intervention studies are needed to confirm the relationship between hydration and aging.
fundraising
This work was funded by the Intramural Research Program of the National Heart, Lung, and Blood Institute (NHLBI). ARIC research is funded in whole or in part by federal funding from NHLBI. National Institutes of Health (NIH); and Department of Health and Human Services.
