team of researchers University of Houston It may have developed a “vaccine” that blocked the ability of fentanyl, a dangerous synthetic opioid, to enter the brain.
Survey results released late last month journal pharmaceuticalshas been described as a potential game-changer in dealing with the epidemic that has claimed the lives of thousands of Americans.
An estimated 150 people die each day from synthetic opioid-related overdose deaths.
(University of Houston)
Fentanyl is 50 times more potent than heroin and 100 times more potent than morphine. A dose of as little as 2 milligrams (2 grains of rice) can be lethal.
Research associate professor Colin Heil, the lead author of the study, said the vaccine “has an antimicrobial that binds to consumed fentanyl, preventing it from entering the brain and allowing it to exit the body through the kidneys.” It is capable of producing fentanyl antibodies.”
“So the individual doesn’t feel the euphoric effect and can ‘get back on the wagon,'” he said.
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He added that the anti-fentanyl antibodies were specific to it and that the fentanyl derivative did not cross-react with other opioids such as morphine. means
Opioid use disorder (OUD) is treatable, but studies show that approximately 80% of opioid addicts relapse.
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A clinical study on the vaccine caused no adverse side effects in the involved immunized rats. The research team will produce a clinical-grade vaccine for human trials in the coming months.
