Exercise has been found to be more medically beneficial than we believe, and its effects are also being felt in the case of neurological disorders. New research shows that it restores cell health in the brain and affects spinocerebellar ataxia 6 (SCA6). Researchers at McGill University who specialize in SCA6 and other forms of ataxia present findings that not only offer hope for patients with SCA6, but also may pave the way for the development of treatments for other movement disorders. Announced.
In particular, spinocerebellar ataxia 6 (SCA6), an inherited neurological disorder that impairs motor coordination that has been reported to affect only about 1 in 100,000 people, has led medical researchers to By the way, little attention has been paid to this condition. It is important to note that there are currently no known treatments and only a few alternative treatments: A study by Anna Cook entitled “Activation of TrkB-Akt Signaling Defects in Her Mouse Model of SCA6”. The results of “save” were published in Science Advances.
exercise with pills
According to McGill’s team, led by professor of biology Alana Watt, in SCA6-affected mice, the health of cells in the cerebellum, the part of the brain implicated in SCA6 and other ataxias, is enhanced by exercise. It turns out that I have recovered. Researchers found that the reason for the improvement was that exercise increased levels of brain-derived neurotrophic factor (BDNF), a naturally occurring substance in the brain that supports the growth and development of nerve cells. Importantly, for patients with movement disorders where exercise is not always possible, the team demonstrated that a drug that mimics the action of BDNF may be as effective as exercise.
Why Early Intervention Matters
Furthermore, the researchers found that BDNF levels in SCA6 mice were reduced long before motor deficits appeared. Interestingly, the drug they discovered worked to stop the decline only when administered before visible symptoms appeared.
Dr. Anna Cook, a candidate for Professor Watt’s lab, said: If there are early changes in the brain that people are unaware of, we tend to advocate for more genetic screening and early intervention for these rare diseases.”
(with input from ANI)
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