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Wednesday, May 1, 2024
An NIH-funded rat project also found widespread differences between male and female organisms.
what
A large-scale research project in young adult rats found that all body tissues tested responded to exercise training, and that over time, even tissues in organs not normally involved in exercise adapted in response to endurance exercise. More than 35,000 biomolecules have been identified as The researchers also found that the differences in responses between male and female rats were more extensive than expected, highlighting the importance of including animals of both sexes in preclinical studies. The National Institutes of Health (NIH)-funded effort used data from thousands of analyzes of 19 tissue types to identify molecular changes in genes, proteins, and metabolites. These substances are essential for the metabolism of specific organisms and the metabolism of living organisms. specific metabolic processes. The findings are published in a series of papers in the journal Nature.
Molecular changes were seen in all tissues, but the way each tissue responded was unique. For example, effects on the function of mitochondria, the cellular centers of energy production and metabolism, were observed throughout the body, but the specific changes observed varied by tissue. For example, researchers found that mitochondria in the adrenal glands responded strongly to endurance training, with changes in the regulation of nearly half of mitochondria-related genes. This was surprising because the role of the adrenal glands in exercise had not previously been studied in detail.
Additionally, they found differences in the molecular responses to endurance exercise between young male and female rats in most tissues tested, including the brain, adrenal glands, lungs, and adipose tissue. Scientists have found significant differences in the response of white adipose tissue between men and women. The findings could play a role in research into how exercise interventions can be recommended to men or women with conditions such as obesity. Sex differences in exercise responses in humans and animals are not well characterized, and these findings highlight the need to include both sexes in future exercise research to fully understand the role of exercise in health. doing.
Scientists are mapping the molecular changes in the body after exercise by tracking the effects of exercise on biomolecules in humans and rats. Studies in rats allow for a wider range of tissue types to be analyzed compared to studies in humans, and the knowledge gained allows researchers to consider different hypotheses and guide researchers in analyzing human data. It will be.
Researchers are currently conducting exercise research on the human body. This will improve our understanding of why the body responds to exercise and how differently people of different ages, genders, body compositions, and fitness levels respond. In the long term, these insights could allow clinicians to recommend specific exercise regimens tailored to patients to treat or prevent a variety of diseases and health conditions.
NIH’s Physical Activity Molecular Transducer Consortium (MoTrPAC)was founded in 2016 to understand at the molecular level how exercise improves and maintains our health. NIH Common Fund Supervised in collaboration with. National Institute on Aging , National Institute of Arthritis, Musculoskeletal and Skin Diseasesand the National Institute of Diabetes and Digestive and Kidney Diseases. For a list of current projects, please visit: https://commonfund.nih.gov/MolecularTransducers/fundedresearch. For more information on adult and pediatric clinical research, please visit: clinicaltrials.gov under NCT03960827 and NCT04151199Or visit Recruitment web page Learn more about how to get involved.
The data obtained through this research project is It has been published Available for further analysis and direct download, encouraging more hypotheses from the biomedical community.
who
Dr. Concepcion Nieras, Office of the Director, Strategic Coordination Bureau
reference
MoTrPAC Research Group. “Temporal dynamics of multiomic responses to endurance exercise training” Nature 2024. DOI number: 10.1038/s41586-023-06877-w
About the NIH Common Fund: The NIH Common Fund encourages collaboration and supports a range of highly impactful NIH-wide programs. The Common Fund Program is managed by the Office of Strategic Coordination in the Division of Program Coordination, Planning, and Strategic Initiatives in the NIH Office of the Director, in collaboration with NIH institutes, centers, and offices. For more information, please visit the Common Fund website. https://commonfund.nih.gov.
About the National Institutes of Health (NIH):The nation’s medical research agency, NIH, has 27 institutes and centers and is part of the U.S. Department of Health and Human Services. NIH is the primary federal agency that conducts and supports basic, clinical, and translational medical research, investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, please visit www.nih.gov.
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