Overview: Children infected with COVID-19 are at increased risk of being diagnosed with type 1 diabetes. Researchers found that new cases of type 1 diabetes in her younger than 18 years with COVID-19 increased by 72%.
sauce: Case Western Reserve
Children infected with COVID-19 have a significantly higher risk of developing type 1 diabetes (T1D), according to a new study that analyzed the electronic health records of more than 1 million patients under the age of 18. increase.
In a study published today in the journal JAMA network openResearchers at Case Western Reserve University School of Medicine report that children and adolescents infected with COVID-19 are more likely to develop T1D within six months of their COVID diagnosis.
Findings showed a 72% increase in new diagnoses of T1D in COVID-19 patients under the age of 18.
About 187,000 children and adolescents under the age of 20 nationwide have T1D, according to the Centers for Disease Control and Prevention (CDC).
“Type 1 diabetes is viewed as an autoimmune disease,” said Pamela Davis, Distinguished University Professor and Corresponding Author of the Paper, Arline H. and Curtis F. Garvin Research Professor at Case Western Reserve School of Medicine. said.
“This primarily occurs because the body’s immune defenses attack the cells that produce insulin, thereby shutting down insulin production and causing disease. COVID has been suggested to increase the autoimmune response. and the current findings reinforce that suggestion.”
The team will study anonymized electronic data collections of approximately 1.1 million patients under the age of 18 in the United States and 13 other countries diagnosed with SARS-CoV-2 infection between March 2020 and December 2021. I analyzed the chart. – COVID-related respiratory infections during the same period.
The study population was further divided into two groups: patients aged up to 9 years and patients aged 10–18 years.After careful statistical checks to account for age, demographics, and family history of diabetes, There were 285,628 in each group for a total of 571,256 patients.
Survey results
The research team found that among more than 571,000 pediatric patients:
- Within 6 months of SARS-CoV2 infection, 123 patients (0.043%) had a new diagnosis of T1D, compared to 72 patients with a new diagnosis after a non-COVID respiratory infection ( 0.025%), new diagnoses.
- At 1, 3, and 6 months post-infection, persons infected with SARS-CoV2 had a significantly higher risk of being diagnosed with T1D than those infected with respiratory infections other than COVID. Similar results were reported in patients aged 9 and 10 to her 18 years of age.
“Families at high risk of type 1 diabetes in their children should be especially aware of post-COVID diabetes symptoms, and pediatricians should be aware of the influx of new cases of type 1 diabetes…children.” Davis said.
“In the months and years to come, there is likely to be a significant increase in the disease. It means that there is
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Corresponding author, Rong Xu, professor of biomedical informatics at the School of Medicine and director of the Center for Artificial Intelligence in Drug Discovery, said, He said further research is needed. A pediatric patient persists and is vulnerable, and how to treat her COVID-19-associated T1D in children.
“We are also investigating possible changes in type 2 diabetes development in children after SARS-CoV2 infection,” said Xu.
Type 2 diabetes (T2D) is known as ‘adult-onset diabetes’ and is often chronically ill over time as patients become resistant to the effects of insulin and subsequently the pancreas does not produce enough insulin. develops over time. to the CDC.
The Case Western Reserve research team also included David Kaelber, professor of internal medicine, pediatrics, population and quantitative health sciences, and medical students Ellen Kendall and Veronica Olaker.
A previous COVID-related study led by the CWRU team found a 50-80% increase in risk factors for Alzheimer’s disease among older adults infected with COVID, while those with dementia were twice as likely to contract COVID. I already know.
About this COVID-19 and diabetes research news
author: press office
sauce: Case Western Reserve
contact: Press Office – Case Western Reserve
image: image is public domain
Original research: Findings are displayed in: JAMA network open
