- Written by Michelle Roberts
- Digital Health Editor
image source, science photo library
British scientists say they have discovered a new cause behind much of the damage caused by asthma.
Their research shows that the cells lining the airways are compressed and destroyed during an attack.
And drugs to prevent this could break the cycle of harm rather than managing its aftermath, said researchers at King’s College London. science journal.
Asthma patients’ airways are sensitive to triggers such as pollen, pets, and exercise.
It becomes inflamed and swollen, causing symptoms such as coughing, wheezing, and shortness of breath.
Existing medications and inhalers can help reduce this inflammation and keep your airways open.
However, repeated attacks can cause permanent scarring and narrowing of the airways.
When an attack occurs, the smooth muscles surrounding the airways begin to compress and tighten, a process known as bronchoconstriction.
A team from King’s College London studied this process in detail using mouse and human lung tissue samples.
Lead researcher Professor Jody Rosenblatt said bronchoconstriction damages the lining of the airways, resulting in long-term inflammation, wound healing and infection leading to further attacks.
Until now, this lining damage had been overlooked, she told BBC News.
“This epithelial lining is the body’s first line of defense against infections and other infections, but it is damaged during an asthma attack,” Professor Rosenblatt said.
“There’s this constant injury going on and it’s a vicious cycle.
“We’re hopeful that if we can block the damage, the attacks might not happen at all.”
“Sorely needed”
One possible preventive treatment researchers are considering is an element called gadolinium, which appears to be effective, at least in mice.
But more research is needed to see if it’s safe and effective enough to try in humans, which could take years.
Dr Samantha Walker, Director of Research and Innovation at Asthma and Lung UK, said: ‘This discovery opens an important new door to exploring the potential for much-needed new treatment options for people with asthma. Yes,” he said.
The charity says it is vital that people with asthma continue to use their prescribed medicines correctly. Many people with asthma should be able to continue living their lives without any problems, and it is important for those who still have symptoms to consult their GP. Doctor; Medical worker.
“We know that existing asthma treatments don’t work for many people, so it’s important that we continue to fund research to find new treatments that can more effectively address the causes of asthma. is.”
More than five million people in the UK have asthma, which equates to around 1 in 12 adults and 1 in 11 children.
Most asthma patients have two inhalers.
- Preventive medications used regularly to reduce inflammation and prevent symptoms
- Relaxant to quickly open airways
If you are having a seizure, do not delay in seeking help and call 999 if:
- their relievers are useless
- attack lasts 4 hours
- they are always worried
