summary: A new study confirms the link between the gut microbiome and Alzheimer’s disease.
This study demonstrated that Alzheimer’s symptoms can be transferred to young, healthy organisms through gut microbiota transplantation. Patients with Alzheimer’s disease have an increased presence of bacteria that cause inflammation, which correlates with the patient’s cognitive status.
This finding highlights the gut microbiome as a crucial area in Alzheimer’s disease research.
Important facts:
- Memory deficits in Alzheimer’s patients can be transferred to younger animals through transplantation of the gut microbiota.
- Increased numbers of bacteria that promote inflammation in the gut are directly linked to cognitive decline in Alzheimer’s patients.
- This study suggests that early intervention by studying the role of gut microbes in the early stages of dementia may lead to new therapeutic approaches.
sauce: UCC
Researchers have discovered a link between the gut microbiome and Alzheimer’s disease.
Researchers have discovered for the first time that symptoms of Alzheimer’s disease can be transmitted to healthy young organisms via the gut microbiome, confirming the role of Alzheimer’s disease in Alzheimer’s disease.
The research was led by Professor Yvonne Nolan from APC Microbiome Ireland, the world’s leading SFI-funded research center based at University College Cork (UCC), and Professor Yvonne Nolan from UCC’s School of Anatomy and Neuroscience. The study was conducted jointly by Professor Sandrine Tourette and Dr Annamaria of King’s College London. Cattaneo IRCCS Fatebenefratelli, Italy.
This study confirms that the gut microbiome is emerging as an important research target for Alzheimer’s disease, given its sensitivity to lifestyle and environmental influences.
was announced on brainThis study shows that memory impairment in Alzheimer’s patients can be transferred to younger animals through gut microbiota transplantation.
Patients with Alzheimer’s disease had higher abundances of pro-inflammatory bacteria in their fecal samples, and these changes were directly associated with patients’ cognitive status.
Professor Yvonne Nolan said: “The memory test we investigated relies on the growth of new neurons in the hippocampal region of the brain. Animals with the gut bacteria of Alzheimer’s patients produced fewer new neurons and had impaired memory. I found out that it is true.”
“Alzheimer’s patients are typically diagnosed at or after the onset of cognitive symptoms, which may be too late, at least with current treatments. “Understanding the role of gut bacteria could pave the way for the development of new treatments and even personalized interventions,” Professor Nolan said.
Alzheimer’s disease is the most common cause of dementia and is a general term for memory loss and other cognitive impairments severe enough to interfere with daily life. As the population ages, one in three people born today could develop Alzheimer’s disease.
Funded by Science Foundation Ireland, UCC scientists are leading the way in healthy brain aging by investigating how the gut microbiome responds to lifestyle influences such as diet and exercise. We are working to develop strategies to accelerate and advance the treatment of Alzheimer’s disease.
Professor Sandrine Thuret, Professor of Neuroscience at King’s College London and one of the study’s senior authors, said: ‘Alzheimer’s disease is an insidious disease and there is still no effective treatment. , representing an important advance in the understanding of this disease, confirming that the composition of our gut microbiota is causally linked to the development of this disease.
“This collaboration has laid the foundation for future research in this area. My hope is that it will lead to potential advances in therapeutic interventions.”
The research was carried out by postdoctoral researcher Dr Stephanie Grubrucker, who is collaborating with Professor Nolan, and by postdoctoral colleagues Dr Edina Siladzic from King’s College London and Dr Moira Marizzoni from IRCCS Fatebene Fratelli in Italy. This was carried out in cooperation with UCC collaborators were Professor Cora O’Neill, Dr Olivia O’Leary, Dr Sarah Nicholas, Dr Jane English, Mr Sebastian Dohm Hansen and Dr Aongus Lovell.
Professor. John F. Cryan, vice president of research and innovation at UCC, who also worked on the study, said: He conducts research into related diseases such as Alzheimer’s disease, and with UCC he recognizes APC Microbiome Ireland as a leading institution in microbiome and brain health research.
“This research is consistent with our UCC Futures Framework and the university’s strategic plans in the areas of food, microbiome, health and, soon to be launched, future aging and brain sciences.”
About this Alzheimer’s disease research news
author: kate o sullivan
sauce: UCC
contact: Kate O Sullivan – UCC
image: Image credited to Neuroscience News
Original research: Open access.
“The microbiota of Alzheimer’s disease patients causes defects in cognition and hippocampal neurogenesisWritten by Yvonne Nolan et al. brain
abstract
The microbiota of Alzheimer’s disease patients causes defects in cognition and hippocampal neurogenesis
Alzheimer’s disease is a complex neurodegenerative disease that causes declines in cognitive function and mental health. Recent studies have demonstrated specific changes in the composition of the gut microbiota in Alzheimer’s disease patients and rodent models, positioning the gut microbiota as an important susceptibility factor for Alzheimer’s disease. However, it is unclear whether changes in the gut microbiome are responsible for the manifestation of Alzheimer’s disease symptoms.
To understand the involvement of the gut microbiota of Alzheimer’s disease patients in host physiology and behavior, we collected fecal microbiota from Alzheimer’s disease patients and age-matched healthy controls with microbiota depletion. transplanted into young adult rats.
In transplanted patients with Alzheimer’s disease, we discovered behavioral deficits that depend on adult hippocampal neurogenesis, a process essential for certain memory functions and mood. Notably, the severity of the disorder was correlated with donor patients’ clinical cognitive scores. Discrete changes in the rat cecal and hippocampal metabolomes were also evident.
Because hippocampal neurogenesis cannot be measured in living humans but is regulated by the systemic environment of the circulatory system, we evaluated the influence of the systemic environment in Alzheimer’s disease on proxy neurogenesis readouts.Serum from Alzheimer’s disease patients reduced neurogenesis in human cells in vitro and was associated with cognitive scores and major microbial genera.
Our findings reveal for the first time that Alzheimer’s disease symptoms can be transmitted to healthy young organisms via the gut microbiota and confirm the causal role of the gut microbiota in Alzheimer’s disease and highlights hippocampal neurogenesis as an intensive cellular process that regulates systemic circulation and the intestine. Mediating factors in Alzheimer’s disease.
