Overview: Lack of sleep alters the structure of DNA in immune cells, increasing the number of immune cells and overreacting, causing inflammation. The study found that catching up on sleep did not reverse this effect.
sauce: Mount Sinai Hospital
Chronic inadequate sleep can negatively affect immune cells, leading to inflammatory and cardiovascular disease, according to new research from Icahn School of Medicine, Mount Sinai. Consistently losing half a night’s sleep may increase your risk.
Research published Sept. 21 Journal of Experimental Medicine, It is the first to show that sleep alters the structure of DNA within immune stem cells that produce white blood cells, also known as immune cells, which has long-lasting effects on inflammation and may contribute to inflammatory disease. It was BC.
Immune cells fight infection, but if there are too many of these cells, they can overreact and cause inflammation. This study is also the first to show that catching up on sleep does not reverse the effects of sleep disturbances.
“This research begins by identifying the biological mechanisms that link sleep and immunological health over time. We show that it loses its protective effect and actually exacerbates infection, and these changes persist over time.
“This is important because it is another important observation that sleep reduces inflammation, and conversely, sleep disruption increases inflammation,” said lead author Filip Swirski, PhD.
“This study highlights the importance of adults consistently getting seven to eight hours of sleep per day to prevent inflammation and disease, especially for those with underlying medical conditions.”
The research team analyzed 14 healthy adults who regularly got eight hours of sleep each night. First, the researchers observed that they slept at least eight hours a night for six weeks. They took blood and analyzed immune cells. The same group of adults then reduced her sleep by 90 minutes each night for six weeks and reanalyzed her blood and immune cells.
At the end of the study, researchers compared blood and cell samples from a full night’s sleep and restricted sleep time.
All participants had significant changes in immune cells (also known as hematopoietic cells) due to sleep deprivation. Their number increased and their DNA structure changed. After six weeks of sleep restriction, the number of immune cells increased.
The researchers also analyzed sleep in mouse models. Groups of mice were either able to sleep undisturbed or had sleep fragmentation and were awake throughout the night for 16 weeks. Restoring sleep without interruption.
The researchers harvested immune stem and immune cells from these undisturbed, fragmented, sleep recovery mice, analyzed them, and compared them at the end of the experiment.
Results in mice were consistent with those in humans. They showed that all mice with fragmented sleep had profound changes in immune stem cells and increased numbers of immune cells, and also showed evidence of rewiring and reprogramming.
A remarkable finding from a mouse group was that immune stem cells retained this rewiring structure even after sleep recovery and continued to produce additional white blood cells, making mice more susceptible to inflammation and disease.
“Our findings suggest that sleep recovery cannot fully reverse the effects of poor quality sleep. can be detected.
“This molecular signature can cause cells to react in inappropriate ways, leading to inflammation and disease,” said co-principal investigator Cameron McAlpine, Ph.D., assistant professor of medicine (cardiology) at Icahn Mount Sinai. said.
“It was surprising to find that not all clusters of stem cells responded to sleep deprivation in the same way. This global decline in diversity and aging of the immune stem cell population is an important cause of inflammatory and cardiovascular disease.”
Funding: The National Heart, Lung, and Blood Institute and the National Center for Advanced Translational Sciences, part of the National Institutes of Health, funded this research.
About this sleep and inflammation research news
author: Ilana Niklavesh
sauce: Mount Sinai Hospital
contact: Ilana Nikravesh – Mount Sinai Hospital
image: image is public domain
Original research: Findings are displayed in: Journal of Experimental Medicine
