Research published in eBio Medicine According to the National Institutes of Health, adults who maintain adequate hydration are healthier and at greater risk of developing chronic diseases such as heart and lung disease than those who don’t drink enough water. It was found that they tended to be low and live long.
The NIH findings may provide early clues about advanced biological aging and increased risk of premature death.
A National Institutes of Health (NIH) study released Jan. 2 found that adults who drink enough water are healthier than those who don’t drink enough water, and their hearts and lungs are healthier. They are less likely to develop chronic diseases such as illness and seem to live longer. , 2023, Journal eBio Medicine.
Using health data collected from 11,255 adults over 30 years, researchers analyzed the association between serum sodium levels (which rise as water intake decreases) and various indicators of health. They found that adults with serum sodium levels in the high end of the normal range were more likely to develop chronic disease and show signs of advanced biological aging than those with serum sodium levels in the moderate range. Adults with higher levels were also more likely to die at a younger age.
“Results suggest that adequate hydration may slow aging and prolong disease-free life.” National Institute of Health (NHLBI), part of the NIH.
The study expands on research published in March 2022 by the scientists, who found a link between a high range of normal serum sodium levels and an increased risk of heart failure. Both findings were obtained from the Atherosclerosis Risk in the Community (ARIC) study. His first ARIC substudy, initiated in his 1987, helped researchers better understand risk factors for heart disease and formed clinical guidelines for its treatment and prevention.
In this latest analysis, researchers assessed information shared with study participants during five medical visits, the first two in their 50s and the last two in those aged 70-90. To allow a fair comparison of how hydration correlates with health outcomes, the researchers investigated whether adults who had high levels of serum sodium at baseline check-in, or who had no effect on serum sodium levels. We excluded adults with underlying medical conditions, such as obesity, that could lead to
Next, we evaluated how serum sodium concentrations correlated with biological aging, assessed by 15 health markers. This includes factors such as systolic blood pressure, cholesterol and blood sugar, providing insight into how well each person’s cardiovascular, respiratory, metabolic, renal and immune systems are functioning. We also adjusted for factors such as age, race, biological sex, smoking status, and hypertension.
They found that adults with high normal serum sodium levels, with a normal range of 135 to 146 milliequivalents per liter (mEq/L), were more likely to show signs of biological aging. This was based on indicators such as metabolic and cardiovascular health, lung function, and inflammation. For example, adults with serum sodium concentrations above 142 mEq/L have a 10–15% increased chance of being biologically older than chronological age compared to those in the range of 137–142 mEq/L,144 50% increase for levels above mEq/L. Similarly, levels of 144.5 to 146 mEq/L were associated with a 21% increased risk of premature death compared to the range of 137 to 142 mEq/L.
Similarly, adults with serum sodium levels greater than 142 mEq/L have up to a 64% increased associated risk of developing chronic diseases such as heart failure, stroke, atrial fibrillation, peripheral artery disease, chronic lung disease, diabetes and dementia. Did. Conversely, adults with serum sodium levels between 138 and 140 mEq/L had the lowest risk of developing chronic disease.
The findings do not prove causality, the researchers noted. Randomized controlled trials are needed to determine whether optimal hydration can promote healthy aging, prevent disease, and extend lifespan. can provide and guide individual health behaviors.
“People with serum sodium above 142 mEq/L would benefit from assessing fluid intake,” said Dmitrieva. She said most people can safely increase their fluid intake to meet recommended levels. of fluids, suggesting men consume 8 to 12 cups (2 to 3 liters) of fluid.
Others may require medical guidance for underlying health conditions. It’s about making sure we’re doing it,” said Manfred Boehm, M.D., study author and director of the Institute for Cardiovascular Regenerative Medicine. “Physicians may also need to follow the patient’s current treatment regimen, including limiting fluid intake for heart failure.”
The authors also cited a study that found that about half of people worldwide do not meet their total daily fluid intake recommendations, which often start at 6 cups (1.5 liters).
“At the global level, this could have a huge impact,” Dmitrieva said. “Dehydration is the most common factor in increasing serum sodium. Therefore, our results suggest that maintaining adequate hydration may slow the aging process and prevent or delay chronic disease.” It is suggested from
Reference: “Normal Serum Sodium in Higher Middle Ages as a Risk Factor for Accelerated Biological Aging, Chronic Disease, and Premature Death” Natalia I. Dmitrieva, Alessandro Gagarin, Delong Liu, Colin O. Wu, Manfred Boehm, 2023 1 2nd of the month, eBio Medicine.
DOI: 10.1016/j.ebiom.2022.104404
This research was supported by the NHLBI’s Intramural Research Department. ARIC research is supported by research contracts from the NHLBI, NIH, and the Department of Health and Human Services.
