fatty liver diseaseapproximately affects 30% More than 100% of the world’s population is growing, raising public health concerns. It occurs when too much fat accumulates in liver cells, impairing their function. Lifestyle changes are the cornerstone of disease management, but recent research offers new hope. resistant starchof a certain kind dietary fibermay significantly reduce liver fat. This study cell metabolismIt was a collaborative research between scientists. China, Germanyand Finland.
The role of the liver and the rise in fatty liver disease
The liver is the central organ of metabolism, processing nutrients, detoxifying harmful substances, and storing energy. However, in today’s world of high-calorie diets and sedentary lifestyles, the liver often stores excess fat. Non-alcoholic fatty liver disease (NAFLD). This state is Alcoholic fatty liver disease (AFLD)primarily due to diet, lack of exercise, and metabolic factors rather than alcohol intake.
Why fatty liver is dangerous
NAFLD usually progresses slowly and often goes unnoticed until it progresses to a more severe stage. In the early stages, fat accumulates in liver cells. If untreated, this can cause Nonalcoholic steatohepatitis (NASH)– A more severe form characterized by inflammation and liver cell damage. If left unchecked, NASH can lead to the following: fibrosis, liver cirrhosis,or Hepatocellular carcinoma (liver cancer).
Relationship between intestinal microbiota and fatty liver disease
The latest research focuses on the gut-liver axis, where the gut microbiome plays an important role in liver health. In NAFLD, an imbalance in gut bacteria can worsen fat accumulation in the liver. Certain bacterial species, e.g. Bacteroides stercolisproduce compounds that affect fat metabolism. Addressing these microbial imbalances has become a promising therapeutic goal.
Researchers from the following countries are participating in this study: Sun Yat-sen University (China), University of Helsinki (Finland),and University of Leipzig (Germany)investigated whether modifying the gut microbiota using resistant starch could effectively treat NAFLD.
Research: Resistant starch and liver fat reduction
This groundbreaking research includes: 200 participants Diagnosed with NAFLD. This was a randomized controlled trial conducted over 4 months, ensuring robust and reliable results. Participants were divided into two groups, with one group receiving resistant starch daily and a control group following a normal diet.
Main findings
- reduction of liver fat: Liver fat content, measured by imaging tests and liver biopsy, was significantly reduced from the mean value in the resistant starch group. 25%～13%. In the control group, fat levels decreased only slightly. 24% to 21%.
- Improving liver enzymes: level of Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST)Markers of liver inflammation and damage were significantly improved in the resistant starch group.
- Changes in the gut microbiome: Ingestion of resistant starch changed the composition of intestinal flora. level of Bacteroides stercolisBacteria involved in fat metabolism in the liver decreased. In animal models, this reduction in bacteria was correlated with a reduction in liver fat. Conversely, if you introduce Bacteroides stercolis Returning to the intestines, fat deposits in the liver increase.
Understanding resistant starch
resistant starch Refers to carbohydrates that escape digestion in the small intestine and reach the colon, where they act as prebiotics and feed beneficial gut bacteria. Unlike regular starch, resistant starch ferments in the intestines and short chain fatty acids (SCFA) It has numerous health benefits, including reducing inflammation and improving insulin sensitivity.
Sources of resistant starch
- cooked and cooled potatoes and rice
- Legumes such as lentils, chickpeas, and black beans
- Whole grains and certain corn varieties
- green bananas and plantains
- Pasta (especially boiled and cooled)
Interestingly, the food cooling process is potato and rice Increased resistant starch content. For example, freshly cooked potatoes have less resistant starch than cooled and reheated potatoes.
Practical implications and dietary recommendations
The authors of this study fist-sized portion Include foods rich in resistant starch in every meal. Beyond its liver-specific benefits, resistant starch improves overall gut health, stabilizes blood sugar levels, and supports weight management.
Potential far-reaching effects
This study, conducted at multiple international centers, demonstrates the feasibility of using dietary therapy to combat complex conditions like NAFLD. Unlike drug therapy, resistant starch offers an accessible, non-invasive, and cost-effective approach that has the potential to benefit millions of people around the world.
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