Kawanishi City Japan, October 26, 2022 /PRNewswire/ — Bone cancer, osteosarcoma, osteomyelitis, malfunction of artificial joints, and bone fractures are common causes of bone loss in humans in everyday life. Although there is a risk of viral infection, it is possible to prepare bone tissue from deceased donor patients. Also, the act itself may be difficult for religious reasons. On the other hand, there is also a method of grafting the patient’s own ilium or calf bone, called autogenous bone grafting, but it should be noted that the amount available is limited. Some studies have reported that autologous bone graft surgery can cause some pain later.
In this respect, the development of bone replacement materials and artificial bones may be a promising technology. In the early stages of development, metals such as titanium and ceramic materials have been explored to create robust bone prostheses. However, it is not compatible with bones and is not suitable for long-term use, especially by children. Since the development of artificial bones composed of hydroxyapatite and β-TCP (tricalcium phosphate) in the 1980s, demand and expectations for this kind of artificial bones have increased rapidly.
However, there was also the problem that the material was hard and it was difficult to adjust the shape. Thus, powders, blocks and pumice stones consisting of hydroxyapatite or β-TCP were developed. However, these materials are difficult to modify in shape and do not meet the demands of actual surgery.
In order to reproduce living tissue similar to human bones, it is necessary to create a precise three-dimensional structure so that it can be applied to actual surgery. In this respect, 3D printers are the best choice for designing the complex structures required for each patient. You can also expect to create custom-made materials and structures to meet your patient’s expectations.
Polylactic acid (PLA) is a biodegradable resin that can be used in the human body and has already been applied as a bone bonding material.
For these reasons, Dr. Ryohei Mori, Daiki TanakaGreen Science Alliance, Hirohisa Iwabayashi has developed a 3D-printable PLA/hydroxyapatite composite to meet these demands and expectations.
Recently, scaffolds for tissue regenerative medicine have been actively studied. As mentioned above, PLA is biodegradable and human compatible, but does not respond to cell proliferation. Therefore, it cannot be applied as an adhesive/bonding material for cell culture or tissue regeneration. Therefore, since the same PLA/hydroxyapatite composite material also contains hydroxyapatite, improvement of bone tissue and development of cultured cells can be expected.
In addition, the Green Science Alliance has prepared functional materials such as biodegradable resin, β-TCP (β-tricalcium phosphate: a substance with higher bone replacement capacity than hydroxyapatite), collagen, and more advanced biotechnology. We aim to create materials.
We will continue to challenge ourselves to create high-quality biomaterials for bone tissue replacement, regenerative medicine such as scaffolds, and cell culture.
contact:
Ryohei Mori
81-72-7598501
[email protected]
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SOURCE Green Science Alliance Co., Ltd.
