Reducing your calorie intake by 12% increases your energy, rejuvenates your muscles, and increases your longevity.
A new long-term study shows that keeping calories in check while maintaining vitamin and mineral levels, known as a calorie-restricted diet, reduces inflammation and increases metabolism.
Caloric restriction has long been known to slow the progression of age-related diseases in animal models. This new study published by the National Institute on Aging (NIH) suggests that the same biological mechanisms may apply to humans.
This diet appears to stimulate healthy aging genes, allowing us to live longer and healthier lives.
The researchers analyzed data from. Comprehensive evaluation of the long-term effects of reducing energy intake (curry), a two-year study supported by the NIA found that if the group was able to reduce calories by 12%, that was enough to activate most of the biological pathways important for healthy aging. .
“Reducing your calorie intake by 12% is possible and can make a huge difference to your health.” Corresponding author and NIA Scientific Director Luigi Ferrucci, MD.
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The research team sought to understand the molecular basis of the benefits seen in limited previous studies of calorie restriction in humans. One study showed that people who underwent calorie restriction lost an average of 20 pounds of muscle mass and weight in the first year and maintained that weight in the second year.
However, despite losing muscle mass, calorie-restricted participants did not lose muscle strength. This shows that caloric restriction improved the amount of force produced by each unit of muscle mass, known as muscle specific force.
for current researchThe scientists used thigh muscle biopsies from CALERIE participants, a randomized control group of young and middle-aged, non-obese, healthy men and women, followed at one- and two-year intervals.
Researchers confirmed that calorie restriction affects the same genetic pathways in humans as it does in mice and non-human primates. For example, when caloric intake is reduced, genes involved in energy production and metabolism are upregulated, inflammatory genes are downregulated, and inflammation is reduced.
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“Inflammation and aging are closely linked, making calorie restriction a powerful approach to prevent the pro-inflammatory conditions that many older adults develop,” Ferrucci said.
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