Jens Jules Horst, a scientist who helped discover and develop drugs such as Ozempic and Wigovy, explained why people are unlikely to continue taking the drug for more than a year or two.
Scientists who pioneered the development of glucagon-like peptide 1 drugs such as Ozempic and Wegovy reveal why many people are likely to quit the drug after just a few years.
Glucagon-like peptide-1 (GLP-1) is a hormone used to treat type 2 diabetes and obesity. It affects satiety by working in the brain and sending signals to the pancreas to increase insulin production, making the body more efficient. Where sugar is processed.
In the last few months, semaglutide-GLP-1 receptor agonists have been marketed under brand names Ozempic and we goby — It’s trending on social media because some Hollywood insiders are using it for weight loss despite not having diabetes or clinical obesity.
in an interview with WiredScientist Jens Jules Horst, winner of the 2021 Warren-Alpert Foundation Award for his work in discovering and developing treatments based on the GLP-1 hormone, says that while drugs work, people want to continue treatment. I explained that I think the possibility of thinking is low. Been on drugs for over 2 years.
“What happens is you lose your appetite and you lose the enjoyment of eating, so I think you pay a price for that,” explains Holst, a professor of biomedical sciences at the University of Copenhagen. “If you like food, the enjoyment is gone.
“So the reason you don’t eat during GLP-1 therapy is because you lose interest in food,” he continued. “That might eventually become a problem. After a year or two, life becomes so miserably boring that it becomes unbearable and you have to go back. .”
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Holst added that drugs such as Ozempic and Wegobee have been on the market since 2005, and studies have shown that people don’t keep taking them long term.
“Like any other drug, you can’t continue using drugs for many reasons,” he told the media outlet, adding that even people who have stopped and then returned to drugs are still likely to continue using them. pointed out to be low. “Because something just happens and I’m not interested in continuing any further.”
“Maybe you think you’re okay now, but later you find out you’re not okay and you go back to therapy. I don’t think it will stay, I just can’t see the image because it hasn’t happened to me with other GLP-1s.It’s a drug,” he added.
who spoke before Ania Jastlebov M.D.A physician scientist in Obesity Medicine at Yale University, he talks about Ozempic, Wegobee, and the rebound weight gain that can occur if you stop taking the medication.
She explained that diabetes and obesity are chronic diseases, so people using these drugs must continue to take them if they want to maintain their weight loss.
“If you have a patient with high blood pressure, and they have high blood pressure, and they start taking antihypertensive drugs and their blood pressure improves, what happens if you stop the drug? But it’s the same with anti-obesity drugs,” Jastrebov said.
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